About
Our research focus
The Leeds Oral Microbiome research group, led by Professor Thuy Do, investigates how microbial communities and host cells interact to shape oral health and disease.
We focus on the oral microbiome, biofilm development, and the cellular responses that influence these processes. By linking microbiology, cell biology, and bioinformatics, we aim to understand the mechanisms that govern oral ecosystem stability, dysbiosis, and disease progression.
Our research sits within Division of Oral Biology in the School of Dentistry, University of Leeds, bringing together expertise in oral microbiology, cell biology, and bioinformatic analysis.
Why the oral microbiome and cell biology matter
The oral cavity is home to one of the most complex microbial communities in the human body.
These microbes don’t act in isolation, they form structured biofilms and interact constantly with host tissues.
Disruptions in this balance contribute to major oral diseases such as caries and periodontitis, and are increasingly linked to systemic conditions.
Understanding how microbes communicate with and influence host cells is essential for developing better preventive, diagnostic, and therapeutic strategies.
Our group works at this interface, generating insights that have relevance across dentistry, microbiology, immunology, and broader biomedical science.
Our approach
We combine wet‑lab experimentation with advanced bioinformatics and imaging to investigate microbial behaviour and host responses at multiple scales.
Our methods include:
- microbial culture and biofilm models
- cell biology assays and host–microbe co culture
- RNA and DNA based sequencing
- confocal and scanning electron microscopy
- bioinformatic analysis using high performance computing
The group works across disciplines, collaborating closely with colleagues in Leeds Teaching Hospitals Trust for valuable clinical insights, as well as international partners from industry and academia.
We maintain active research links globally, including an ongoing collaboration and formal agreement with the University of Brasília Dental School, which supports joint projects, student exchanges, and shared methodological development.
Lab culture and values
We are an open, supportive, and collaborative team. Our culture is built on curiosity, integrity, and respect for diverse perspectives and backgrounds.
We emphasise rigorous science, transparent data practices, and an environment where students and researchers can grow their skills and confidence.
Team members are encouraged to work independently while benefiting from regular group discussions, cross‑disciplinary input, and shared problem‑solving.
We value international cooperation and believe that tackling complex biological questions requires collective effort and a willingness to learn from others.
Above all, we aim to create a welcoming space where good science, and good scientists, can thrive.